Carbapenem- and Colistin-Resistant Enterobacter cloacae from Delta, Colorado, in 2015 | Zendy

Andrew P. Norgan | Zendy; Jarred M. Freese | Zendy; Patricia M. Tuin | Zendy; Scott A. Cunningham | Zendy; Patricio Jeraldo | Zendy; Robin Patel | Zendy

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Carbapenem- and Colistin-Resistant Enterobacter cloacae from Delta, Colorado, in 2015

Author(s) -

Andrew P. Norgan,

Jarred M. Freese,

Patricia M. Tuin,

Scott A. Cunningham,

Patricio Jeraldo,

Robin Patel

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03055-15

Subject(s) - colistin , enterobacter cloacae , polymyxin , efflux , microbiology and biotechnology , carbapenem , biology , tigecycline , enterobacteriaceae , enterobacter , carbapenem resistant enterobacteriaceae , antibiotics , mcr 1 , medicine , gene , genetics , escherichia coli

Resistance to carbapenems in Enterobacteriaceae is a clinical problem of growing significance. Difficulty in treating multidrug-resistant Gram-negative organisms with conventional antibiotics has led to a renewed and increasing use of polymyxin compounds, such as colistin. Here, we report the isolation of carbapenem- and colistin-resistant Enterobacter cloacae from a polymicrobial lower extremity wound in an ambulatory patient. Whole-genome sequencing demonstrated the presence of chromosomal blaIMI-1 and blaAmpC, as well as numerous efflux pump genes.

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