Chloroquine Remains Effective for Treating Plasmodium vivax Malaria in Pursat Province, Western Cambodia | Zendy

Chanaki Amaratunga | Zendy; Sokunthea Sreng | Zendy; Sivanna Mao | Zendy; Gregory Tullo | Zendy; Jennifer M. Anderson | Zendy; Char Meng Chuor | Zendy; Seila Suon | Zendy; Rick M. Fairhurst | Zendy

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Chloroquine Remains Effective for Treating Plasmodium vivax Malaria in Pursat Province, Western Cambodia

Author(s) -

Chanaki Amaratunga,

Sokunthea Sreng,

Sivanna Mao,

Gregory Tullo,

Jennifer M. Anderson,

Char Meng Chuor,

Seila Suon,

Rick M. Fairhurst

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03026-14

Subject(s) - malaria , plasmodium vivax , chloroquine , plasmodium falciparum , artemisinin , vivax malaria , drug resistance , virology , medicine , piperaquine , biology , immunology , microbiology and biotechnology

Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported. The use of artemisinin (ART)-based combination therapies (ACTs) to treat CQ-sensitive P. vivax infections is effective and convenient but may promote the emergence and worsening of ART resistance in sympatric Plasmodium falciparum populations. Here, we show that CQ effectively treats P. vivax malaria in Pursat Province, western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading. (This study has been registered at ClinicalTrials.gov under registration no. NCT00663546.).

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