Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine | Zendy

Chi Eziefula | Zendy; Helmi Pett | Zendy; Lynn Grignard | Zendy; Salome Opus | Zendy; Moses Ν. Kiggundu | Zendy; Moses R. Kamya | Zendy; Shunmay Yeung | Zendy; Sarah G. Staedke | Zendy; Teun Bousema | Zendy; Chris Drakeley | Zendy

Open Access

Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine

Author(s) -

Chi Eziefula,

Helmi Pett,

Lynn Grignard,

Salome Opus,

Moses Ν. Kiggundu,

Moses R. Kamya,

Shunmay Yeung,

Sarah G. Staedke,

Teun Bousema,

Chris Drakeley

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02889-14

Subject(s) - primaquine , glucose 6 phosphate dehydrogenase , hemolysis , glucose 6 phosphate dehydrogenase deficiency , malaria , plasmodium falciparum , hemolytic anemia , glucosephosphate dehydrogenase deficiency , heterozygote advantage , dehydrogenase , biology , hemoglobin , hemoglobinopathy , enzyme , immunology , medicine , genotype , biochemistry , gene , chloroquine

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

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