In Vitro Activities of Nine Antifungal Drugs and Their Combinations against Phialophora verrucosa | Zendy

Yali Li | Zendy; Zhe Wan | Zendy; Ruoyu Li | Zendy

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In Vitro Activities of Nine Antifungal Drugs and Their Combinations against Phialophora verrucosa

Author(s) -

Yali Li,

Zhe Wan,

Ruoyu Li

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02875-14

Subject(s) - caspofungin , itraconazole , micafungin , flucytosine , posaconazole , voriconazole , amphotericin b , terbinafine , fluconazole , pharmacology , microbiology and biotechnology , biology , medicine , antifungal

The in vitro activities of nine antifungal drugs and their combinations against 31 clinical and 15 environmental Phialophora verrucosa strains were tested. The MIC90/90% minimum effective concentration (MIC/MEC90) values (μg/ml) across all strains were as follows: for terbinafine, 0.25; for posaconazole, 0.5; for voriconazole, 1; for itraconazole, 2; for amphotericin B, 4; for caspofungin and micafungin, 16; and for fluconazole and flucytosine, 64. The highest synergy was shown by the combination of itraconazole plus caspofungin (with synergy against 100% of the 31 clinical strains), followed by amphotericin B plus flucytosine (45.2%) and itraconazole plus terbinafine or micafungin (25.8% or 12.9%, respectively).

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