Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro | Zendy

Hannelore I. Bax | Zendy; Irma A. J. M. BakkerWoudenberg | Zendy; Marian T. ten Kate | Zendy; Annelies Verbon | Zendy; Jurriaan E.M. de Steenwinkel | Zendy

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Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro

Author(s) -

Hannelore I. Bax,

Irma A. J. M. BakkerWoudenberg,

Marian T. ten Kate,

Annelies Verbon,

Jurriaan E.M. de Steenwinkel

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02864-15

Subject(s) - tigecycline , clarithromycin , microbiology and biotechnology , antibiotics , antibacterial agent , pharmacology , protein synthesis inhibitor , medicine , biology

Thein vitroactivities of clarithromycin and tigecycline alone and in combination againstMycobacterium aviumwere assessed. The activity of clarithromycin was time dependent, highly variable, and often resulted in clarithromycin resistance. Tigecycline showed concentration-dependent activity, and mycobacterial killing could only be achieved at high concentrations. Tigecycline enhanced clarithromycin activity againstM. aviumand prevented clarithromycin resistance. Whether there is clinical usefulness of tigecycline in the treatment ofM. aviuminfections needs further study.

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