The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri | Zendy

Evgeny A. Idelevich | Zendy; Frieder Schaumburg | Zendy; Dennis Knaack | Zendy; Anna S. Scherzinger | Zendy; Wolfgang Mutter | Zendy; Georg Peters | Zendy; Andreas Peschel | Zendy; Karsten Becker | Zendy

Open Access

The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri

Author(s) -

Evgeny A. Idelevich,

Frieder Schaumburg,

Dennis Knaack,

Anna S. Scherzinger,

Wolfgang Mutter,

Georg Peters,

Andreas Peschel,

Karsten Becker

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02859-15

Subject(s) - staphylococcus aureus , microbiology and biotechnology , lysin , bacteriophage , biology , staphylococcus , antibiotics , recombinant dna , in vitro , methicillin resistant staphylococcus aureus , bacteria , escherichia coli , genetics , gene

HY-133 is a recombinant bacteriophage endolysin with bactericidal activity againstStaphylococcus aureus . Here, HY-133 showedin vitro activity against major African methicillin-susceptible and methicillin-resistantS. aureus lineages and ceftaroline/ceftobiprole- and borderline oxacillin-resistant isolates. HY-133 was also active againstStaphylococcus schweitzeri , a recently described species of theS. aureus complex. The activity of HY-133 on the tested isolates (MIC50 , 0.25 μg/ml; MIC90 , 0.5 μg/ml; range, 0.125 to 0.5 μg/ml) was independent of the species and strain background or antibiotic resistance.

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