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HY-133 is a recombinant bacteriophage endolysin with bactericidal activity againstStaphylococcus aureus . Here, HY-133 showedin vitro activity against major African methicillin-susceptible and methicillin-resistantS. aureus lineages and ceftaroline/ceftobiprole- and borderline oxacillin-resistant isolates. HY-133 was also active againstStaphylococcus schweitzeri , a recently described species of theS. aureus complex. The activity of HY-133 on the tested isolates (MIC50 , 0.25 μg/ml; MIC90 , 0.5 μg/ml; range, 0.125 to 0.5 μg/ml) was independent of the species and strain background or antibiotic resistance.

antimicrobial agents and chemotherapy

The Recombinant Bacteriophage Endolysin HY-133 Exhibits <i>In Vitro</i> Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri

The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri