Antimalarial Activity of Tulathromycin in a Murine Model of Malaria | Zendy

Nicolás F. Villarino | Zendy; Joshua E. Denny | Zendy; Nathan W. Schmidt | Zendy

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Antimalarial Activity of Tulathromycin in a Murine Model of Malaria

Author(s) -

Nicolás F. Villarino,

Joshua E. Denny,

Nathan W. Schmidt

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02858-14

Subject(s) - plasmodium yoelii , malaria , clearance , parasite hosting , pharmacology , biology , medicine , immunology , plasmodium falciparum , parasitemia , world wide web , computer science , urology

There is an urgent need for new antimalarial agents and strategies to treat and control malaria. This study shows an antiplasmodium effect of tulathromycin in mice infected with Plasmodium yoelii. The administration of tulathromycin around the time of infection prevented the progression of disease in 100% of the animals. In addition, highly parasitized mice treated with tulathromycin showed a decreased parasite burden and cleared the parasite faster than did untreated infected mice.

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