Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense | Zendy

Keisuke Suganuma | Zendy; Albertus Eka Yudistira Sarwono | Zendy; Shinya Mitsuhashi | Zendy; Marcin Jąkalski | Zendy; Tadashi Okada | Zendy; Molefe Nthatisi | Zendy; Junya Yamagishi | Zendy; Makoto Ubukata | Zendy; Noboru Inoue | Zendy

Open Access

Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense

Author(s) -

Keisuke Suganuma,

Albertus Eka Yudistira Sarwono,

Shinya Mitsuhashi,

Marcin Jąkalski,

Tadashi Okada,

Molefe Nthatisi,

Junya Yamagishi,

Makoto Ubukata,

Noboru Inoue

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02816-15

Subject(s) - mycophenolic acid , imp dehydrogenase , trypanosoma , trypanocidal agent , pharmacology , inosine , biology , chemistry , biochemistry , enzyme , trypanosoma brucei , virology , medicine , transplantation , surgery , gene

This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense The proliferation of T. congolense was completely inhibited by adding <1 μM MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs.

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