Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum | Zendy

Fiona McCallum | Zendy; Ivor Harris | Zendy; Karin van Breda | Zendy; Sai Lata De | Zendy; Danielle I. Stanisic | Zendy; Michael F. Good | Zendy; David P. Jacobus | Zendy; Michael D. Edstein | Zendy

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Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum

Author(s) -

Fiona McCallum,

Ivor Harris,

Karin van Breda,

Sai Lata De,

Danielle I. Stanisic,

Michael F. Good,

David P. Jacobus,

Michael D. Edstein

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02799-15

Subject(s) - plasmodium falciparum , in vivo , quinine , in vitro , chloroquine , biology , cell culture , virology , malaria , microbiology and biotechnology , immunology , biochemistry , genetics

Previously, we reported JPC-2997 (4-(tert-Butyl)-2-((tert-butylamino)methyl)-6-(6- (trifluoromethyl)pyridin-3-yl)-phenol) to possess high in vitro antimalarial activity against Plasmodium falciparum lines, low cytotoxicity in mammalian cell lines, long blood elimination half-life in Aotus monkeys (10.8 days) and potent in vivo efficacy against animal malaria models (1).….

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