Open AccessAntimicrobial Activities of Ceftaroline and Comparator Agents against Bacterial Organisms Causing Bacteremia in Patients with Skin and Skin Structure Infections in U.S. Medical Centers, 2008 to 2014
Author(s) -
Hélio S. Sader,
Robert K. Flamm,
Rodrigo E. Mendes,
David J. Farrell,
Ronald N. Jones
Publication year - 2016
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02794-15
Subject(s) - staphylococcus aureus , klebsiella pneumoniae , microbiology and biotechnology , antimicrobial , bacteremia , tigecycline , medicine , methicillin resistant staphylococcus aureus , staphylococcal skin infections , acinetobacter baumannii , escherichia coli , antibiotics , biology , pseudomonas aeruginosa , bacteria , gene , biochemistry , genetics
We evaluated the antimicrobial susceptibility of 1,454 organisms consecutively collected from patients with bacteremia associated with skin and skin structure infections. The most common organisms obtained wereStaphylococcus aureus(670 organisms [46.1%]),Escherichia coli(200 organisms [13.8%]), β-hemolytic streptococci (βHS) (138 organisms [9.5%]), andKlebsiella pneumoniae(109 organisms [7.5%]). The susceptibility rates for ceftaroline were 97.9% forS. aureus(95.9% among methicillin-resistantS. aureus[MRSA]), 100.0% for βHS, 86.5% forE. coli, and 89.0% forK. pneumoniae Ceftaroline and tigecycline provided the best overall coverage.
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