Strain Types and Antimicrobial Resistance Patterns of Clostridium difficile Isolates from the United States, 2011 to 2013 | Zendy

Isabella A. Tickler | Zendy; Richard V. Goering | Zendy; Joseph Whitmore | Zendy; Ashley N. W. Lynn | Zendy; David H. Persing | Zendy; Fred C. Tenover | Zendy

Open Access

Strain Types and Antimicrobial Resistance Patterns of Clostridium difficile Isolates from the United States, 2011 to 2013

Author(s) -

Isabella A. Tickler,

Richard V. Goering,

Joseph Whitmore,

Ashley N. W. Lynn,

David H. Persing,

Fred C. Tenover

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02775-13

Subject(s) - clindamycin , clostridium difficile , microbiology and biotechnology , moxifloxacin , ribotyping , biology , vancomycin , antimicrobial , antibiotic resistance , strain (injury) , clostridium , antibiotics , genotype , bacteria , genetics , staphylococcus aureus , gene , anatomy

We determined the PCR ribotypes and antimicrobial susceptibility patterns of 508 toxigenic Clostridium difficile isolates collected between 2011 and 2013 from 32 U.S. hospitals. Of the 29 PCR ribotypes identified, the 027 strain type was the most common (28.1%), although the rates varied by geographic region. Ribotype 014/020 isolates appear to be emerging. Clindamycin and moxifloxacin resistances (36.8% and 35.8%, respectively) were the most frequent resistance phenotypes observed. Reduced susceptibility to vancomycin was observed in 39.1% of 027 isolates.

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