Complete Sequencing of IncI1 Sequence Type 2 Plasmid pJIE512b Indicates Mobilization of bla CMY-2 from an IncA/C Plasmid | Zendy

Kaitlin A. Tagg | Zendy; Jonathan R. Iredell | Zendy; Sally R. Partridge | Zendy

Open Access

Complete Sequencing of IncI1 Sequence Type 2 Plasmid pJIE512b Indicates Mobilization of bla _CMY-2 from an IncA/C Plasmid

Author(s) -

Kaitlin A. Tagg,

Jonathan R. Iredell,

Sally R. Partridge

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02773-14

Subject(s) - plasmid , sequence (biology) , context (archaeology) , biology , complete sequence , genetics , gene , genome , paleontology

Sequencing of pJIE512b, a 92.3-kb IncI1 sequence type 2 (ST2) plasmid carrying bla(CMY-2), revealed a bla(CMY-2) context that appeared to have been mobilized from an IncA/C plasmid by the insertion sequence IS1294. A comparison with published plasmids suggests that bla(CMY-2) has been mobilized from IncA/C to IncI1 plasmids more than once by IS1294-like elements. Alignment of pJIE512b with the only other available IncI1 ST2 plasmid revealed differences across the backbones, indicating variability within this sequence type.

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