Complete Nucleotide Sequence of Two Multidrug-Resistant IncR Plasmids from Klebsiella pneumoniae | Zendy

Fabrice Compain | Zendy; Lionel Frangeul | Zendy; Laurence Drieux | Zendy; Charlotte Verdet | Zendy; Sylvain Brisse | Zendy; Guillaume Arlet | Zendy; Dominique Decré | Zendy

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Complete Nucleotide Sequence of Two Multidrug-Resistant IncR Plasmids from Klebsiella pneumoniae

Author(s) -

Fabrice Compain,

Lionel Frangeul,

Laurence Drieux,

Charlotte Verdet,

Sylvain Brisse,

Guillaume Arlet,

Dominique Decré

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02773-13

Subject(s) - replicon , plasmid , transposable element , biology , klebsiella pneumoniae , genetics , multiple drug resistance , gene , nucleic acid sequence , insertion sequence , microbiology and biotechnology , antibiotics , escherichia coli , genome

We report here the complete nucleotide sequence of two IncR replicons encoding multidrug resistance determinants, including β-lactam (blaDHA-1, blaSHV-12), aminoglycoside (aphA1, strA, strB), and fluoroquinolone (qnrB4, aac6'-1b-cr) resistance genes. The plasmids have backbones that are similar to each other, including the replication and stability systems, and contain a wide variety of transposable elements carrying known antibiotic resistance genes. This study confirms the increasing clinical importance of IncR replicons as resistance gene carriers.

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