Pharmacokinetics of Ofloxacin and Levofloxacin for Prevention and Treatment of Multidrug-Resistant Tuberculosis in Children | Zendy

Stephanie Thee | Zendy; Anthony J. GarciaPrats | Zendy; Helen McIlleron | Zendy; Lubbe Wiesner | Zendy; Sandra Castel | Zendy; Jennifer Norman | Zendy; Heather R. Draper | Zendy; P L van der Merwe | Zendy; Anneke C. Hesseling | Zendy; H. Simon Schaaf | Zendy

Open Access

Pharmacokinetics of Ofloxacin and Levofloxacin for Prevention and Treatment of Multidrug-Resistant Tuberculosis in Children

Author(s) -

Stephanie Thee,

Anthony J. GarciaPrats,

Helen McIlleron,

Lubbe Wiesner,

Sandra Castel,

Jennifer Norman,

Heather R. Draper,

P L van der Merwe,

Anneke C. Hesseling,

H. Simon Schaaf

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02755-13

Subject(s) - ofloxacin , levofloxacin , pharmacokinetics , medicine , pharmacology , pharmacodynamics , tuberculosis , drug , antibiotics , antibacterial agent , oral administration , quinolone , ciprofloxacin , microbiology and biotechnology , biology , pathology

Limited data on fluoroquinolone pharmacokinetics and cardiac effects in children exist. Among 22 children receiving drug-resistant tuberculosis prophylaxis or treatment, serum concentrations following oral doses of levofloxacin (15 mg/kg of body weight) and ofloxacin (20 mg/kg) were lower than those expected from existing pediatric data, possibly due to differences in the formulations (crushed tablets). Drug exposures were lower than those in adults following standard doses and below the proposed pharmacodynamic targets, likely due to more rapid elimination in children. No QT prolongation was observed.

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