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We determined thein vitro activity of fenticonazole against 318 vaginitis isolates ofCandida and bacterial species and selected 28 isolates for time-kill studies. At concentrations equal to 4× MIC, fenticonazole reached the 99.9% killing endpoint by ∼10 h forStaphylococcus aureus ,Streptococcus agalactiae , andEscherichia coli and by ∼17 h forCandida albicans andCandida parapsilosis ; and at concentrations equal to 8× MIC, by ∼19 and ∼20 h forCandida glabrata andCandida tropicalis , respectively.

In Vitro Activity of Fenticonazole against Candida and Bacterial Vaginitis Isolates Determined by Mono- or Dual-Species Testing Assays