In Vitro Activity of Fenticonazole against Candida and Bacterial Vaginitis Isolates Determined by Mono- or Dual-Species Testing Assays | Zendy

Maurizio Sanguinetti | Zendy; Rafael Cantón | Zendy; Riccardo Torelli | Zendy; Fabio Tumietto | Zendy; Ana EspinelIngroff | Zendy; Brunella Posteraro | Zendy

Open Access

In Vitro Activity of Fenticonazole against Candida and Bacterial Vaginitis Isolates Determined by Mono- or Dual-Species Testing Assays

Author(s) -

Maurizio Sanguinetti,

Rafael Cantón,

Riccardo Torelli,

Fabio Tumietto,

Ana EspinelIngroff,

Brunella Posteraro

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02693-18

Subject(s) - microbiology and biotechnology , candida glabrata , candida albicans , staphylococcus aureus , candida tropicalis , streptococcus agalactiae , biology , candida parapsilosis , vaginitis , corpus albicans , minimum inhibitory concentration , fluconazole , streptococcus , antimicrobial , bacteria , antifungal , genetics

We determined thein vitro activity of fenticonazole against 318 vaginitis isolates ofCandida and bacterial species and selected 28 isolates for time-kill studies. At concentrations equal to 4× MIC, fenticonazole reached the 99.9% killing endpoint by ∼10 h forStaphylococcus aureus ,Streptococcus agalactiae , andEscherichia coli and by ∼17 h forCandida albicans andCandida parapsilosis ; and at concentrations equal to 8× MIC, by ∼19 and ∼20 h forCandida glabrata andCandida tropicalis , respectively.

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