Amino Acid Biosynthetic Pathways Are Required for Klebsiella pneumoniae Growth in Immunocompromised Lungs and Are Druggable Targets during Infection | Zendy

Rebecca J. Silver | Zendy; Michelle K. Paczosa | Zendy; Anne L. McCabe | Zendy; Joan-Miquel Balada-Llasat | Zendy; James Baleja | Zendy; Joan Mecsas | Zendy

Open Access

Amino Acid Biosynthetic Pathways Are Required for Klebsiella pneumoniae Growth in Immunocompromised Lungs and Are Druggable Targets during Infection

Author(s) -

Rebecca J. Silver,

Michelle K. Paczosa,

Anne L. McCabe,

Joan-Miquel Balada-Llasat,

James Baleja,

Joan Mecsas

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02674-18

Subject(s) - klebsiella pneumoniae , druggability , microbiology and biotechnology , biology , amino acid , virology , biochemistry , escherichia coli , gene

The emergence of multidrug-resistantKlebsiella pneumoniae has rendered a large array of infections difficult to treat. In a high-throughput genetic screen of factors required forK. pneumoniae survival in the lung, amino acid biosynthesis genes were critical for infection in both immunosuppressed and wild-type (WT) mice.

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