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The emergence of multidrug-resistantKlebsiella pneumoniae has rendered a large array of infections difficult to treat. In a high-throughput genetic screen of factors required forK. pneumoniae survival in the lung, amino acid biosynthesis genes were critical for infection in both immunosuppressed and wild-type (WT) mice.

antimicrobial agents and chemotherapy

Amino Acid Biosynthetic Pathways Are Required for <i>Klebsiella pneumoniae</i> Growth in Immunocompromised Lungs and Are Druggable Targets during Infection

Amino Acid Biosynthetic Pathways Are Required for Klebsiella pneumoniae Growth in Immunocompromised Lungs and Are Druggable Targets during Infection