Comparative Study of Activities of a Diverse Set of Antimycobacterial Agents against Mycobacterium tuberculosis and Mycobacterium ulcerans | Zendy

Nicole Scherr | Zendy; Gerd Pluschke | Zendy; Manoranjan Panda | Zendy

Open Access

Comparative Study of Activities of a Diverse Set of Antimycobacterial Agents against Mycobacterium tuberculosis and Mycobacterium ulcerans

Author(s) -

Nicole Scherr,

Gerd Pluschke,

Manoranjan Panda

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02658-15

Subject(s) - mycobacterium ulcerans , buruli ulcer , antimycobacterial , mycobacterium tuberculosis , tuberculosis , microbiology and biotechnology , mycobacterium , virology , minimum inhibitory concentration , biology , antimicrobial , medicine , disease , pathology

A library of compounds covering a broad chemical space was selected from a tuberculosis drug development program and was screened in a whole-cell assay against Mycobacterium ulcerans, the causative agent of the necrotizing skin disease Buruli ulcer. While a number of potent antitubercular agents were only weakly active or inactive against M. ulcerans, five compounds showed high activity (90% inhibitory concentration [IC90], ≤1 μM), making screening of focused antitubercular libraries a good starting point for lead generation against M. ulcerans.

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