Small-Molecule Morphogenesis Modulators Enhance the Ability of 14-Helical β-Peptides To Prevent Candida albicans Biofilm Formation | Zendy

Angélica de L. Rodríguez López | Zendy; MyungRyul Lee | Zendy; Nathan Wang | Zendy; Kaitlin K. Dunn | Zendy; Hiram Sánchez | Zendy; Namrata Raman | Zendy; David R. Andes | Zendy; David M. Lynn | Zendy; Sean P. Palecek | Zendy

Open Access

Small-Molecule Morphogenesis Modulators Enhance the Ability of 14-Helical β-Peptides To Prevent Candida albicans Biofilm Formation

Author(s) -

Angélica de L. Rodríguez López,

MyungRyul Lee,

Nathan Wang,

Kaitlin K. Dunn,

Hiram Sánchez,

Namrata Raman,

David R. Andes,

David M. Lynn,

Sean P. Palecek

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02653-18

Subject(s) - candida albicans , biofilm , morphogenesis , microbiology and biotechnology , small molecule , chemistry , biology , biophysics , biochemistry , bacteria , genetics , gene

Candida albicans is an opportunistic fungal pathogen responsible for mucosal candidiasis and systemic candidemia in humans. Often, these infections are associated with the formation of drug-resistant biofilms on the surfaces of tissues or medical devices. Increased incidence ofC. albicans resistance to current antifungals has heightened the need for new strategies to prevent or eliminate biofilm-related fungal infections.

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