Complete Nucleotide Sequences of Two VIM-1-Encoding Plasmids from Klebsiella pneumoniae and Leclercia adecarboxylata Isolates of Czech Origin | Zendy

Ivo Papoušek | Zendy; Costas C. Papagiannitsis | Zendy; Matej Medvecký | Zendy; Jaroslav Hrabák | Zendy; Monika Dolejská | Zendy

Open Access

Complete Nucleotide Sequences of Two VIM-1-Encoding Plasmids from Klebsiella pneumoniae and Leclercia adecarboxylata Isolates of Czech Origin

Author(s) -

Ivo Papoušek,

Costas C. Papagiannitsis,

Matej Medvecký,

Jaroslav Hrabák,

Monika Dolejská

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02648-16

Subject(s) - plasmid , integron , klebsiella pneumoniae , biology , multiple drug resistance , sequence (biology) , insertion sequence , nucleic acid sequence , complete sequence , microbiology and biotechnology , enterobacteriaceae , genetics , virology , gene , escherichia coli , drug resistance , transposable element , genome

Two multidrug resistance (MDR) plasmids, carrying the VIM-1-encoding integron In110, were characterized. Plasmid pLec-476cz (311,758 bp), from a Leclercia adecarboxylata isolate, consisted of an IncHI1 backbone, a MDR region, and two accessory elements. Plasmid pKpn-431cz (142,876 bp), from a sequence type 323 (ST323) Klebsiella pneumoniae isolate, comprised IncFII Y -derived and pKPN3-like sequences and a mosaic region. A 40,400-bp sequence of pKpn-431cz was identical to the MDR region of pLec-476cz, indicating the en bloc acquisition of the VIM-1-encoding region from one plasmid by the other.

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