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Candida guilliermondii shows intrinsic reduced echinocandin susceptibility. It harbors two polymorphisms (L633M and T634A) in the Fks1p hot spot 1 region. Our objective was to confirm that the reduced echinocandin susceptibility ofC. guilliermondii is due to those naturally occurring substitutions. We constructed aSaccharomyces cerevisiae mutant in which a region of theFKS1 gene (including hot spot 1) was replaced with that fromC. guilliermondii . The chimeric mutants showed 32-fold increases in echinocandin MIC values, confirming the hypothesis.

antimicrobial agents and chemotherapy

Molecular Confirmation of the Relationship between Candida guilliermondii Fks1p Naturally Occurring Amino Acid Substitutions and Its Intrinsic Reduced Echinocandin Susceptibility