Open AccessHeavy Metal Resistance Genes Are Associated with bla NDM-1 - and bla CTX-M-15 -Carrying Enterobacteriaceae
Author(s) -
Qiu Yang,
Siham R. Agouri,
Jonathan M. Tyrrell,
Timothy R. Walsh
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02642-17
Subject(s) - enterobacteriaceae , plasmid , microbiology and biotechnology , biology , gene , multiple drug resistance , drug resistance , genetics , escherichia coli
The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing bla NDM-1 or bla CTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA , merA , silC , and arsA genes occurred with higher frequencies in bla NDM-1 -positive (48.8% to 71.8%) and bla CTX-M-15 -positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae , increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.
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