Anti-Candida Activity of Fluoxetine Alone and Combined with Fluconazole: a Synergistic Action against Fluconazole-Resistant Strains | Zendy

Ana Sofia Oliveira | Zendy; Carlos Gaspar | Zendy; Rita PalmeiradeOliveira | Zendy; José MartinezdeOliveira | Zendy; Ana PalmeiradeOliveira | Zendy

Open Access

Anti-Candida Activity of Fluoxetine Alone and Combined with Fluconazole: a Synergistic Action against Fluconazole-Resistant Strains

Author(s) -

Ana Sofia Oliveira,

Carlos Gaspar,

Rita PalmeiradeOliveira,

José MartinezdeOliveira,

Ana PalmeiradeOliveira

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02623-13

Subject(s) - fluconazole , fluoxetine , vulvovaginal candidiasis , microbiology and biotechnology , minimum inhibitory concentration , antimicrobial , pharmacology , azole , biology , chemistry , medicine , antifungal , receptor , biochemistry , serotonin

The purpose of this work was to determine the antimicrobial activity of fluoxetine, alone and combined with fluconazole, against 29 Candida strains isolated from patients with vulvovaginal candidiasis. MIC and minimum lethal concentration values ranged from 9.8 to 625 μg/ml for all strains tested. The combination of fluconazole with fluoxetine resulted in synergistic activity against six Candida strains, with fractional inhibitory index (FIX) values between 0.15 and 0.31. An indifferent effect was found for the remaining strains, with FIX values between 0.63 and 1.

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