Treatment of Multidrug-Resistant Vancomycin-Resistant Enterococcus faecium Hardware-Associated Vertebral Osteomyelitis with Oritavancin plus Ampicillin | Zendy

Samira Dahesh | Zendy; Brian J. F. Wong | Zendy; Victor Nizet | Zendy; George Sakoulas | Zendy; Truc T. Tran | Zendy; Samuel L Aitken | Zendy

Open Access

Treatment of Multidrug-Resistant Vancomycin-Resistant Enterococcus faecium Hardware-Associated Vertebral Osteomyelitis with Oritavancin plus Ampicillin

Author(s) -

Samira Dahesh,

Brian J. F. Wong,

Victor Nizet,

George Sakoulas,

Truc T. Tran,

Samuel L Aitken

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02622-18

Subject(s) - enterococcus faecium , ampicillin , vancomycin , medicine , enterococcus , osteomyelitis , antibiotics , amp resistance , vertebral osteomyelitis , vancomycin resistant enterococcus , microbiology and biotechnology , biology , surgery , staphylococcus aureus , bacteria , genetics

Weekly oritavancin plus ampicillin continuous infusion combination therapy was used to successfully treat a deep spine vancomycin-resistant Enterococcus faecium infection associated with hardware. Checkerboard and time-kill assays confirmed synergy between these two antibiotics. Further synergies of oritavancin and ampicillin with rifampin or the endogenous human antimicrobial peptide cathelicidin LL-37 were demonstrated.

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