A Novel Hybrid Plasmid Carrying Multiple Antimicrobial Resistance and Virulence Genes in Salmonella enterica Serovar Dublin | Zendy

Chand S. Mangat | Zendy; Sadjia Békal | Zendy; Rebecca Irwin | Zendy; Michael R. Mulvey | Zendy

Open Access

A Novel Hybrid Plasmid Carrying Multiple Antimicrobial Resistance and Virulence Genes in Salmonella enterica Serovar Dublin

Author(s) -

Chand S. Mangat,

Sadjia Békal,

Rebecca Irwin,

Michael R. Mulvey

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02601-16

Subject(s) - plasmid , virulence , salmonella enterica , microbiology and biotechnology , biology , salmonella , serotype , enterobacteriaceae , operon , insertion sequence , antibiotic resistance , gene , virology , genetics , antibiotics , escherichia coli , bacteria , transposable element , genome

Virulence plasmids and antibiotic resistance plasmids are usually maintained separately inSalmonella spp.; however, we report an instance of a hybrid plasmid (pN13-01125) inSalmonella enterica serovar Dublin. Review of the complete sequence of the 172,265-bp plasmid suggests that pN13-01125 is comprised of the previously described pSDVr and pSH696_135 plasmids and that the mechanism of hybridization likely involves IS6 (IS26 ) insertion sequence elements. The plasmid has a low conjugation frequency, confers resistance to six classes of antimicrobials, and contains a completespv virulence operon.

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