Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections | Zendy

Sylvain Goutelle | Zendy; Sandrine Roux | Zendy; MarieClaude Gagnieu | Zendy; Florent Valour | Zendy; Sébastien Lustıg | Zendy; Florence Ader | Zendy; Frédéric Laurent | Zendy; Christian Chidiac | Zendy; Tristan Ferry | Zendy

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Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

Author(s) -

Sylvain Goutelle,

Sandrine Roux,

MarieClaude Gagnieu,

Florent Valour,

Sébastien Lustıg,

Florence Ader,

Frédéric Laurent,

Christian Chidiac,

Tristan Ferry

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02597-15

Subject(s) - daptomycin , pharmacokinetics , medicine , renal function , population , therapeutic drug monitoring , pharmacology , biology , vancomycin , environmental health , bacteria , genetics , staphylococcus aureus

The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and was significantly higher in male than in female patients. We observed significant intraindividual changes in daptomycin clearance, which were uncorrelated with changes in renal function, suggesting that therapeutic drug monitoring is important in patients receiving prolonged daptomycin therapy.

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