Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus | Zendy

Hyun Lee | Zendy; Susan BoyleVavra | Zendy; Jinhong Ren | Zendy; Jamie Jarusiewicz | Zendy; Lalit Kumar Sharma | Zendy; Daniel Hoagland | Zendy; Shaohui Yin | Zendy; Tian Zhu | Zendy; Kirk E. Hevener | Zendy; Isabel Ojeda | Zendy; Richard Lee | Zendy; Robert S. Daum | Zendy; Michael E. Johnson | Zendy

Open Access

Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus

Author(s) -

Hyun Lee,

Susan BoyleVavra,

Jinhong Ren,

Jamie Jarusiewicz,

Lalit Kumar Sharma,

Daniel Hoagland,

Shaohui Yin,

Tian Zhu,

Kirk E. Hevener,

Isabel Ojeda,

Richard Lee,

Robert S. Daum,

Michael E. Johnson

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02593-18

Subject(s) - staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , identification (biology) , antibiotics , biology , micrococcaceae , staphylococcal infections , antibacterial agent , bacteria , chemistry , genetics , botany

Methicillin-resistantStaphylococcus aureus (MRSA) strains that are resistant to all forms of penicillin have become an increasingly common and urgent problem threatening human health. They are responsible for a wide variety of infectious diseases ranging from minor skin abscesses to life-threatening severe infections. Thevra operon that is conserved amongS. aureus strains encodes a three-component signal transduction system (vraTSR ) that is responsible for sensing and responding to cell wall stress.

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