Bordetella pertussis Lipid A Glucosamine Modification Confers Resistance to Cationic Antimicrobial Peptides and Increases Resistance to Outer Membrane Perturbation | Zendy

Nita R. Shah | Zendy; Robert E. W. Hancock | Zendy; Rachel C. Fernandez | Zendy

Open Access

Bordetella pertussis Lipid A Glucosamine Modification Confers Resistance to Cationic Antimicrobial Peptides and Increases Resistance to Outer Membrane Perturbation

Author(s) -

Nita R. Shah,

Robert E. W. Hancock,

Rachel C. Fernandez

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02590-14

Subject(s) - bordetella pertussis , lipid a , bacterial outer membrane , microbiology and biotechnology , glucosamine , lipopolysaccharide , cathelicidin , antimicrobial , antimicrobial peptides , immune system , chemistry , bacteria , biology , biochemistry , immunology , escherichia coli , genetics , gene

Bordetella pertussis, the causative agent of whooping cough, has many strategies for evading the human immune system. Lipopolysaccharide (LPS) is an important Gram-negative bacterial surface structure that activates the immune system via Toll-like receptor 4 and enables susceptibility to cationic antimicrobial peptides (CAMPs). We show modification of the lipid A region of LPS with glucosamine increased resistance to numerous CAMPs, including LL-37. Furthermore, we demonstrate that this glucosamine modification increased resistance to outer membrane perturbation.

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