Complete Sequence of a KPC-Producing IncN Multidrug-Resistant Plasmid from an Epidemic Escherichia coli Sequence Type 131 Strain in China | Zendy

Liang Chen | Zendy; Hongyan Hu | Zendy; Kalyan D. Chavda | Zendy; Shulong Zhao | Zendy; Renkun Liu | Zendy; Hui Liang | Zendy; Wei Zhang | Zendy; Xiumei Wang | Zendy; Michael R. Jacobs | Zendy; Robert A. Bonomo | Zendy; Barry N. Kreiswirth | Zendy

Open Access

Complete Sequence of a KPC-Producing IncN Multidrug-Resistant Plasmid from an Epidemic Escherichia coli Sequence Type 131 Strain in China

Author(s) -

Liang Chen,

Hongyan Hu,

Kalyan D. Chavda,

Shulong Zhao,

Renkun Liu,

Hui Liang,

Wei Zhang,

Xiumei Wang,

Michael R. Jacobs,

Robert A. Bonomo,

Barry N. Kreiswirth

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02587-13

Subject(s) - biology , plasmid , escherichia coli , microbiology and biotechnology , gene , multiple drug resistance , genetics , nucleic acid sequence , drug resistance , virology

We report here the nucleotide sequence of a novelbla KPC-2 -harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistantEscherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genesbla KPC-2 ,bla CTX-M-3 , andbla TEM-1 ; aminoglycoside acetyltransferase geneaac (6 ′)-Ib-cr ; quinolone resistance geneqnrS1 ; rifampin resistance genearr-3 ; and trimethoprim resistance genedfrA14 . The emergence of abla KPC-2 -harboring multidrug-resistant plasmid in an epidemicE. coli ST131 clone poses a significant potential threat in community and hospital settings.

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