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We report here the nucleotide sequence of a novelbla KPC-2 -harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistantEscherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genesbla KPC-2 ,bla CTX-M-3 , andbla TEM-1 ; aminoglycoside acetyltransferase geneaac (6 ′)-Ib-cr ; quinolone resistance geneqnrS1 ; rifampin resistance genearr-3 ; and trimethoprim resistance genedfrA14 . The emergence of abla KPC-2 -harboring multidrug-resistant plasmid in an epidemicE. coli ST131 clone poses a significant potential threat in community and hospital settings.

Complete Sequence of a KPC-Producing IncN Multidrug-Resistant Plasmid from an Epidemic Escherichia coli Sequence Type 131 Strain in China