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Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal againstAcinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associatedA. baumannii CFU reductions of &gt;4 log10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was &gt;50 and maximum concentration of drug in serum (C max )/MIC was ≈10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, includingA. baumannii .

Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model