Outbreak Caused by NDM-1- and RmtB-Producing Escherichia coli in Bulgaria | Zendy

Laurent Poirel | Zendy; Encho Savov | Zendy; Arzu Nazlı | Zendy; Angelina Trifonova | Zendy; Ива Тодорова | Zendy; Ivanka Gergova | Zendy; Patrice Nordmann | Zendy

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Outbreak Caused by NDM-1- and RmtB-Producing Escherichia coli in Bulgaria

Author(s) -

Laurent Poirel,

Encho Savov,

Arzu Nazlı,

Angelina Trifonova,

Ива Тодорова,

Ivanka Gergova,

Patrice Nordmann

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02571-13

Subject(s) - escherichia coli , outbreak , microbiology and biotechnology , biology , colonization , multilocus sequence typing , virology , genotype , genetics , gene

Twelve consecutive carbapenem-resistant Escherichia coli isolates were recovered from patients (infection or colonization) hospitalized between March and September 2012 in different units at a hospital in Bulgaria. They all produced the carbapenemase NDM-1 and the extended-spectrum-β-lactamase CTX-M-15, together with the 16S rRNA methylase RmtB, conferring high-level resistance to all aminoglycosides. All those isolates were clonally related and belonged to the same sequence type, ST101. In addition to being the first to identify NDM-producing isolates in Bulgaria, this is the very first study reporting an outbreak of NDM-1-producing E. coli in the world.

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