Open AccessAntibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases
Author(s) -
O.A. Pemberton,
Xiujun Zhang,
Derek A. Nichols,
Kyle DeFrees,
Priyadarshini Jaishankar,
Richard Bonnet,
Jessie Adams,
Lindsey N. Shaw,
Adam R. Renslo,
Yu Chen
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02563-17
Subject(s) - tetrazole , serine , chemistry , serine protease , biochemistry , stereochemistry , biology , enzyme , protease
CTX-M is the most prevalent family of extended-spectrum β-lactamases. We recently developed a tetrazole-derived noncovalent inhibitor of CTX-M-9.
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