qnrE1 , a Member of a New Family of Plasmid-Located Quinolone Resistance Genes, Originated from the Chromosome of Enterobacter Species | Zendy

Ezequiel Albornoz | Zendy; Nathalie Tijet | Zendy; Denise De Belder | Zendy; Sonia Gómez | Zendy; Florencia Martino | Zendy; Alejandra Corso | Zendy; Roberto G. Melano | Zendy; Alejandro Petroni | Zendy

Open Access

qnrE1 , a Member of a New Family of Plasmid-Located Quinolone Resistance Genes, Originated from the Chromosome of Enterobacter Species

Author(s) -

Ezequiel Albornoz,

Nathalie Tijet,

Denise De Belder,

Sonia Gómez,

Florencia Martino,

Alejandra Corso,

Roberto G. Melano,

Alejandro Petroni

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02555-16

Subject(s) - klebsiella pneumoniae , plasmid , biology , genetics , gene , phylogenetic tree , enterobacter , chromosome , allele , quinolone , microbiology and biotechnology , enterobacteriaceae , escherichia coli , antibiotics

qnrE1 , found in a clinical Klebsiella pneumoniae isolate, was undetectable by PCR assays used for the six qnr families. qnrE1 was located on a conjugative plasmid (ca. 185 kb) and differed from qnrB alleles by 25%. Phylogenetic reconstructions of qnr genes and proteins and analysis of the qnrE1 surroundings showed that this gene belongs to a new qnr family and was likely mobilized by IS Ecp1 from the chromosome of Enterobacter spp. to plasmids of K. pneumoniae .

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