Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models | Zendy

Luisa Christensen | Zendy; R. S. Turner | Zendy; Sean Weaver | Zendy; Francesco Caserta | Zendy; Lisa Long | Zendy; Mahmoud A. Ghannoum | Zendy; Marc B. Brown | Zendy

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Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models

Author(s) -

Luisa Christensen,

R. S. Turner,

Sean Weaver,

Francesco Caserta,

Lisa Long,

Mahmoud A. Ghannoum,

Marc B. Brown

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02554-16

Subject(s) - miconazole nitrate , penetration (warfare) , nail (fastener) , in vitro , miconazole , nail plate , pharmacology , medicine , chemistry , dermatology , materials science , antifungal , biochemistry , mathematics , operations research , metallurgy , psoriasis

In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.

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