NDM-8 Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli Strain Isolated in Nepal | Zendy

Tatsuya Tada | Zendy; Tohru MiyoshiAkiyama | Zendy; Rajan K. Dahal | Zendy; Manoj Kumar Sah | Zendy; Hiroshi Ohara | Zendy; Teruo Kirikae | Zendy; Bharat Mani Pokhrel | Zendy

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NDM-8 Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli Strain Isolated in Nepal

Author(s) -

Tatsuya Tada,

Tohru MiyoshiAkiyama,

Rajan K. Dahal,

Manoj Kumar Sah,

Hiroshi Ohara,

Teruo Kirikae,

Bharat Mani Pokhrel

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02553-12

Subject(s) - escherichia coli , microbiology and biotechnology , multiple drug resistance , strain (injury) , enterobacteriaceae , biology , chemistry , antibiotics , gene , genetics , anatomy

A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistantEscherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. The amino acid sequence of NDM-8 has substitutions at positions 130 (Asp to Gly) and 154 (Met to Leu) compared with NDM-1. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1.

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