Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016 | Zendy

Katariovović | Zendy; Anika Trudić | Zendy; Snežana Brkić | Zendy; Zorica Vasiljević | Zendy; Milan Kojić | Zendy; Deana Medić | Zendy; Ivana Ćirković | Zendy; Branko Jovčić | Zendy

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Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016

Author(s) -

Katariovović,

Anika Trudić,

Snežana Brkić,

Zorica Vasiljević,

Milan Kojić,

Deana Medić,

Ivana Ćirković,

Branko Jovčić

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02550-16

Subject(s) - klebsiella pneumoniae , colistin , mcr 1 , microbiology and biotechnology , biology , gene , enterobacteriaceae , molecular epidemiology , antibiotics , genetics , escherichia coli , genotype

Twenty-seven colistin-resistant, carbapenemase-producingKlebsiella pneumoniae isolates were identified from hospitals in Serbia. All isolates werebla CTX-M-15 positive; ST101, ST888, ST437, ST336, and ST307 werebla OXA-48 positive; and ST340 wasbla NDM-1 positive. ST307 had an insertion, and ST336 had a premature stop codon in themgrB gene. Amino acid substitutions were detected in PmrAB of isolates ST101, ST888, ST336, and ST307. Themcr-1 andmcr-2 were not detected. An increase inphoP ,phoQ , andpmrK gene transcription was detected for all sequence types.

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