External Evaluation of Population Pharmacokinetic Models of Vancomycin in Large Cohorts of Intensive Care Unit Patients | Zendy

Tingjie Guo | Zendy; Reinier M. van Hest | Zendy; Luca F. Roggeveen | Zendy; Lucas M. Fleuren | Zendy; Patrick Thoral | Zendy; Rob J. Bosman | Zendy; Peter H. J. van der Voort | Zendy; Armand R. J. Girbes | Zendy; Ron A. A. Mathôt | Zendy; Paul Elbers | Zendy

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External Evaluation of Population Pharmacokinetic Models of Vancomycin in Large Cohorts of Intensive Care Unit Patients

Author(s) -

Tingjie Guo,

Reinier M. van Hest,

Luca F. Roggeveen,

Lucas M. Fleuren,

Patrick Thoral,

Rob J. Bosman,

Peter H. J. van der Voort,

Armand R. J. Girbes,

Ron A. A. Mathôt,

Paul Elbers

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02543-18

Subject(s) - medicine , pharmacokinetics , dosing , vancomycin , intensive care unit , population , nonmem , volume of distribution , regimen , therapeutic drug monitoring , biology , environmental health , bacteria , genetics , staphylococcus aureus

Dosing of vancomycin is often guided by therapeutic drug monitoring and population pharmacokinetic models in the intensive care unit (ICU). The validity of these models is crucial, as ICU patients have marked pharmacokinetic variability.

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