Plasmodium falciparum Isolates Carrying pf k13 Polymorphisms Harbor the SVMNT Allele of pfcrt in Northwestern Indonesia | Zendy

Inke Nadia Diniyanti Lubis | Zendy; Hendri Wijaya | Zendy; Munar Lubis | Zendy; Chairuddin P. Lubis | Zendy; Khalid B. Beshir | Zendy; Colin J. Sutherland | Zendy

Open Access

Plasmodium falciparum Isolates Carrying pf k13 Polymorphisms Harbor the SVMNT Allele of pfcrt in Northwestern Indonesia

Author(s) -

Inke Nadia Diniyanti Lubis,

Hendri Wijaya,

Munar Lubis,

Chairuddin P. Lubis,

Khalid B. Beshir,

Colin J. Sutherland

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02539-19

Subject(s) - artemisinin , plasmodium falciparum , malaria , biology , virology , allele , regimen , genetics , medicine , gene , immunology

Artemisinin-based combination therapy (ACT) is the first-line antimalarial regimen in Indonesia. Susceptibility ofPlasmodium falciparum to artemisinin is falling in the Greater Mekong subregion, but it is not known whether the efficacy of current combinations is also threatened in nearby Sumatera. We evaluated the genetic locipfcrt, pfmdr1 , andpfk13 , considered to be under selection by artemisinin combination therapy, among 404P. falciparum infections identified by PCR detection in a cross-sectional survey of 3,731 residents of three regencies.

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