In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics | Zendy

Evgeny A. Idelevich | Zendy; André Kriegeskorte | Zendy; Nina Schleimer | Zendy; Georg Peters | Zendy; Christof von Eiff | Zendy; Karsten Becker | Zendy

Open Access

In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics

Author(s) -

Evgeny A. Idelevich,

André Kriegeskorte,

Nina Schleimer,

Georg Peters,

Christof von Eiff,

Karsten Becker

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02532-17

Subject(s) - staphylococcus aureus , antibiotics , microbiology and biotechnology , lactam , biology , in vitro , phenotype , staphylococcus , bacteria , chemistry , genetics , gene , stereochemistry

TheStaphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most β-lactam and non-β-lactam antibioticsin vitro as their corresponding clonally identical strains with a normal phenotype. After prolonged incubation, a regrowth phenomenon has been observed in gradient diffusion inhibition zones irrespective of the strains' phenotype.

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