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Thebla VIM-2 -carrying In58 integron has been linked to a chromosomal location in different bacterial species, includingPseudomonas aeruginosa . This work reports the first fully sequenced In58-harboring plasmid, which is significantly different from the two previously identifiedbla VIM-2 -carrying plasmids inP. aeruginosa .bla VIM-2 might have been acquired by transposition of Tn6352 , a novel transposon composed of the In58 and ISPa17 elements. The recognition of similar inverted repeat (IR) sites by ISPa17 reveals a common mobilization process associated with acquisition of thebla VIM-2 andbla VIM-1 genes.

antimicrobial agents and chemotherapy

Characterization of the pJB12 Plasmid from Pseudomonas aeruginosa Reveals Tn 6352 , a Novel Putative Transposon Associated with Mobilization of the bla VIM-2 -Harboring In58 Integron