High Prevalence of Bedaquiline Resistance in Treatment-Naive Tuberculosis Patients and Verapamil Effectiveness | Zendy

Hasan Ghajavand | Zendy; Mansour Kargarpour Kamakoli | Zendy; Sharareh Khanipour | Zendy; Shahin Pourazar Dizaji | Zendy; Morteza Masoumi | Zendy; Fatemeh Rahimi Jamnani | Zendy; Abolfazl Fateh | Zendy; Seyed Davar Siadat | Zendy; Farzam Vaziri | Zendy

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High Prevalence of Bedaquiline Resistance in Treatment-Naive Tuberculosis Patients and Verapamil Effectiveness

Author(s) -

Hasan Ghajavand,

Mansour Kargarpour Kamakoli,

Sharareh Khanipour,

Shahin Pourazar Dizaji,

Morteza Masoumi,

Fatemeh Rahimi Jamnani,

Abolfazl Fateh,

Seyed Davar Siadat,

Farzam Vaziri

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02530-18

Subject(s) - bedaquiline , verapamil , tuberculosis , medicine , regimen , efflux , drug resistance , multiple drug resistance , pharmacology , microbiology and biotechnology , mycobacterium tuberculosis , biology , pathology , calcium , genetics

In the regions where bedaquiline (BDQ) is introduced into the regimen, analysis of MIC and screening for preexisting resistance mutations could be crucial. The high prevalence of isolates with high BDQ MICs without prior exposure to BDQ was worrisome.

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