Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy | Zendy

Roberto Sánchez-Sánchez | Zendy; Ignacio Ferre | Zendy; Michela Re | Zendy; Juan José Ramos | Zendy; Javier RegidorCerrillo | Zendy; Manuel Pizarro Díaz | Zendy; Marta GonzálezHuecas | Zendy; Enrique Tabanera | Zendy; Júlio Benavides | Zendy; Andrew Hemphill | Zendy; Matthew A. Hulverson | Zendy; Lynn K. Barrett | Zendy; Ryan Choi | Zendy; Grant R. Whitman | Zendy; Kayode K. Ojo | Zendy; Wesley C. Van Voorhis | Zendy; Luis Miguel OrtegaMora | Zendy

Open Access

Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy

Author(s) -

Roberto Sánchez-Sánchez,

Ignacio Ferre,

Michela Re,

Juan José Ramos,

Javier RegidorCerrillo,

Manuel Pizarro Díaz,

Marta GonzálezHuecas,

Enrique Tabanera,

Júlio Benavides,

Andrew Hemphill,

Matthew A. Hulverson,

Lynn K. Barrett,

Ryan Choi,

Grant R. Whitman,

Kayode K. Ojo,

Wesley C. Van Voorhis,

Luis Miguel OrtegaMora

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02527-18

Subject(s) - toxoplasma gondii , fetus , antibody , biology , pregnancy , abortion , immunology , medicine , genetics

Previous studies on drug efficacy showed low protection against abortion and vertical transmission ofToxoplasma gondii in pregnant sheep. Bumped kinase inhibitors (BKIs), which are ATP-competitive inhibitors of calcium-dependent protein kinase 1 (CDPK1), were shown to be highly efficacious against several apicomplexan parasitesin vitro and in laboratory animal models.

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