A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens | Zendy

YuWei Lin | Zendy; Ke Chen | Zendy; Jiping Wang | Zendy; Tony Velkov | Zendy; Qi Zhou | Zendy; Jian Li | Zendy

Open Access

A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens

Author(s) -

YuWei Lin,

Ke Chen,

Jiping Wang,

Tony Velkov,

Qi Zhou,

Jian Li

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02527-17

Subject(s) - polymyxin , colistin , acinetobacter baumannii , pseudomonas aeruginosa , klebsiella pneumoniae , microbiology and biotechnology , polymyxin b , antibiotics , medicine , multiple drug resistance , burn wound , biology , wound healing , immunology , bacteria , biochemistry , gene , genetics , escherichia coli

The efficacy of subcutaneously administered polymyxins against burn wound infections caused by Pseudomonas aeruginosa , Acinetobacter baumannii , and Klebsiella pneumoniae was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B (30 mg/kg thrice daily) achieved a ≥2-log 10 reduction in the bacterial load for P. aeruginosa and A. baumannii infections, whereas wound infections by K. pneumoniae were less responsive (<1-log 10 reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research