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The efficacy of subcutaneously administered polymyxins against burn wound infections caused by Pseudomonas aeruginosa , Acinetobacter baumannii , and Klebsiella pneumoniae was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B (30 mg/kg thrice daily) achieved a ≥2-log 10 reduction in the bacterial load for P. aeruginosa and A. baumannii infections, whereas wound infections by K. pneumoniae were less responsive (&lt;1-log 10 reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections.

antimicrobial agents and chemotherapy

A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens