A Novel Combination of CYP51A Mutations Confers Pan-Azole Resistance in Aspergillus fumigatus | Zendy

Daiana Macedo | Zendy; Tomás Brito Devoto | Zendy; Santiago Pola | Zendy; J. L. Finquelievich | Zendy; María L. Cuestas | Zendy; Guillermo GarcíaEffrón | Zendy

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A Novel Combination of CYP51A Mutations Confers Pan-Azole Resistance in Aspergillus fumigatus

Author(s) -

Daiana Macedo,

Tomás Brito Devoto,

Santiago Pola,

J. L. Finquelievich,

María L. Cuestas,

Guillermo GarcíaEffrón

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02501-19

Subject(s) - posaconazole , aspergillus fumigatus , voriconazole , microbiology and biotechnology , itraconazole , azole , biology , triazole , chemistry , antifungal , organic chemistry

The treatment of invasive and chronic aspergillosis involves triazole drugs. Its intensive use has resulted in the selection of resistant isolates, and at present, azole resistance inAspergillus fumigatus is considered an emerging threat to public health worldwide. The aim of this work is to uncover the molecular mechanism implicated in the azole resistance phenotype of threeAspergillus fumigatus clinical strains isolated from an Argentinian cystic fibrosis patient under long-term triazole treatment.

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