Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection | Zendy

Yara Almeida Machado | Zendy; Maria Terezinha Bahia | Zendy; Ivo Santana Caldas | Zendy; Ana Lia Mazzeti | Zendy; Rômulo Dias Novaes | Zendy; Breno Raimundo Vilas Boas | Zendy; Lorena Júnia de Souza Santos | Zendy; Olindo Assis Martins-Filho | Zendy; Marcos José Marques | Zendy; Lívia de Figueiredo Diniz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection

Author(s) -

Yara Almeida Machado,

Maria Terezinha Bahia,

Ivo Santana Caldas,

Ana Lia Mazzeti,

Rômulo Dias Novaes,

Breno Raimundo Vilas Boas,

Lorena Júnia de Souza Santos,

Olindo Assis Martins-Filho,

Marcos José Marques,

Lívia de Figueiredo Diniz

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02497-19

Subject(s) - trypanosoma cruzi , amlodipine , pharmacology , medicine , biology , virology , blood pressure , parasite hosting , world wide web , computer science

Mining existing agents that enhance the therapeutic potential of ergosterol biosynthesis inhibitors (EBI) is a promising approach to improve Chagas disease chemotherapy. In this study, we evaluated the effect of ravuconazole, an EBI, combined with amlodipine, a calcium channel blocker, uponTrypanosoma cruzi experimental infection.In vitro assays confirmed the trypanocidal activity of both compounds in monotherapy and demonstrated an additive effect (sum of the fractional inhibitory concentration [ΣFIC] > 0.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research