AUC/MIC Pharmacodynamic Target Is Not a Good Predictor of Vancomycin Efficacy in Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis | Zendy

Ximena Castañeda | Zendy; C. García-de-la-Mària | Zendy; Oriol Gasch | Zendy; Juan M. Pericàs | Zendy; Yolanda Armero | Zendy; Dolors Soy | Zendy; Javier GarcíaGonzález | Zendy; Carlos Falces | Zendy; Salvador Pié i Ninot | Zendy; Manel Almela | Zendy; Juan Ambrosioni | Zendy; Eduard Quintana | Zendy; Bárbara Vidal | Zendy; David Fuster | Zendy; Jaume Llopis | Zendy; Sara M. Soto | Zendy; Asunción Moreno | Zendy; Francesc Marco | Zendy; José M. Miró | Zendy

Open Access

AUC/MIC Pharmacodynamic Target Is Not a Good Predictor of Vancomycin Efficacy in Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis

Author(s) -

Ximena Castañeda,

C. García-de-la-Mària,

Oriol Gasch,

Juan M. Pericàs,

Yolanda Armero,

Dolors Soy,

Javier GarcíaGonzález,

Carlos Falces,

Salvador Pié i Ninot,

Manel Almela,

Juan Ambrosioni,

Eduard Quintana,

Bárbara Vidal,

David Fuster,

Jaume Llopis,

Sara M. Soto,

Asunción Moreno,

Francesc Marco,

José M. Miró

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02486-16

Subject(s) - vancomycin , methicillin resistant staphylococcus aureus , staphylococcus aureus , pharmacodynamics , endocarditis , medicine , interquartile range , broth microdilution , microbiology and biotechnology , area under the curve , minimum inhibitory concentration , antibiotics , pharmacokinetics , biology , bacteria , genetics

The aim of thisin vivo study was to compare the efficacy of vancomycin at standard doses (VAN-SD) to that of VAN at adjusted doses (VAN-AD) in achieving a VAN area under the curve/MIC ratio (AUC/MIC) of ≥400 against three methicillin-resistantStaphylococcus aureus (MRSA) strains with different microdilution VAN MICs in an experimental endocarditis model. The valve vegetation bacterial counts after 48 h of VAN therapy were compared, and no differences were observed between the two treatment groups for any of the three strains tested. Overall, for VAN-SD and VAN-AD, the rates of sterile vegetations were 15/45 (33.3%) and 21/49 (42.8%) (P = 0.343), while the medians (interquartile ranges [IQRs]) for log10 CFU/g of vegetation were 2 (0 to 6.9) and 2 (0 to 4.5) (P = 0.384), respectively. In conclusion, this VAN AUC/MIC pharmacodynamic target was not a good predictor of vancomycin efficacy in MRSA experimental endocarditis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research