Isavuconazole Diffusion in Infected Human Brain | Zendy

Claire Rouzaud | Zendy; Vincent Jullien | Zendy; Anne Herbrecht | Zendy; Bruno Palmier | Zendy; Simona Lapusan | Zendy; Marjolaine Morgand | Zendy; Romain Guéry | Zendy; Amélie Duréault | Zendy; François Danion | Zendy; Stéphanie Puget | Zendy; Lauriane Goldwirt | Zendy; Fanny Lanternier | Zendy; Olivier Lortholary | Zendy

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Isavuconazole Diffusion in Infected Human Brain

Author(s) -

Claire Rouzaud,

Vincent Jullien,

Anne Herbrecht,

Bruno Palmier,

Simona Lapusan,

Marjolaine Morgand,

Romain Guéry,

Amélie Duréault,

François Danion,

Stéphanie Puget,

Lauriane Goldwirt,

Fanny Lanternier,

Olivier Lortholary

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02474-18

Subject(s) - chronic lymphocytic leukemia , aspergillosis , complication , medicine , chronic granulomatous disease , leukemia , pathology , surgery , immunology

We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The patients required radical surgery for infection progression despite adequate isavuconazole plasma concentration or neurological complication. We thus decided to measure the brain isavuconazole concentration.

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