Open AccessPharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels
Author(s) -
Siri Kurland,
Mia Furebring,
Elisabeth Löwdin,
Erik Eliasson,
Elisabet I. Nielsen,
Jan Sjölin
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02466-18
Subject(s) - pharmacokinetics , medicine , volume of distribution , bilirubin , gastroenterology , interquartile range , intensive care unit , hypoalbuminemia , albumin , liver function , pharmacology
Caspofungin has a liver-dependent metabolism. Reduction of the dose is recommended based on Child-Pugh (C-P) score.
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