Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City | Zendy

Brandon Eilertson | Zendy; Liang Chen | Zendy; Kalyan D. Chavda | Zendy; Barry N. Kreiswirth | Zendy

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Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City

Author(s) -

Brandon Eilertson,

Liang Chen,

Kalyan D. Chavda,

Barry N. Kreiswirth

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02458-16

Subject(s) - klebsiella pneumoniae , plasmid , biology , enterobacteriaceae , klebsiella , transposable element , microbiology and biotechnology , pandemic , genetics , genome , virology , gene , escherichia coli , covid-19 , medicine , disease , pathology , infectious disease (medical specialty)

Klebsiella pneumoniae carbapenemase (KPC)-producingEnterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003bla KPC -harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producingK. pneumoniae andK .michiganensis isolates collected from a New York City hospital in 1997. Although identified in two differentKlebsiella species, thebla KPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids.

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