Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa | Zendy

Paulo Juarez | Zendy; Isabelle Broutin | Zendy; Christophe Bordi | Zendy; Patrick Plésiat | Zendy; Catherine Llanes | Zendy

Open Access

Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa

Author(s) -

Paulo Juarez,

Isabelle Broutin,

Christophe Bordi,

Patrick Plésiat,

Catherine Llanes

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02445-17

Subject(s) - pseudomonas aeruginosa , overproduction , microbiology and biotechnology , biology , bacteria , amino acid , chemistry , biochemistry , genetics , gene

When overproduced, the multidrug efflux system MexEF-OprN increases the resistance ofPseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory genemexT result in oligomerization of the LysR regulator MexT, constitutive upregulation of the efflux pump, and increased resistance in clinical isolates.

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