A Parasite Biomarker Set for Evaluating Benznidazole Treatment Efficacy in Patients with Chronic Asymptomatic Trypanosoma cruzi Infection | Zendy

Adriana Egui | Zendy; M. Carmen Thomas | Zendy; Ana FernándezVillegas | Zendy; Elena Pérez-Antón | Zendy; Inmaculada Gómez | Zendy; Bartolomé Carrilero | Zendy; Ángel del Pozo | Zendy; Maialen Ceballos | Zendy; Eduardo AndrésLeón | Zendy; Miguel Ángel LópezRuz | Zendy; Eusebio Gaínza | Zendy; Enrique Oquiñena | Zendy; Manuel Segovia | Zendy; Manuel Carlos López | Zendy

Open Access

A Parasite Biomarker Set for Evaluating Benznidazole Treatment Efficacy in Patients with Chronic Asymptomatic Trypanosoma cruzi Infection

Author(s) -

Adriana Egui,

M. Carmen Thomas,

Ana FernándezVillegas,

Elena Pérez-Antón,

Inmaculada Gómez,

Bartolomé Carrilero,

Ángel del Pozo,

Maialen Ceballos,

Eduardo AndrésLeón,

Miguel Ángel LópezRuz,

Eusebio Gaínza,

Enrique Oquiñena,

Manuel Segovia,

Manuel Carlos López

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02436-18

Subject(s) - benznidazole , trypanosoma cruzi , chagas disease , context (archaeology) , asymptomatic , nifurtimox , biology , immunology , virology , medicine , parasite hosting , paleontology , world wide web , computer science

One of the current greatest challenges of Chagas disease is the establishment of biomarkers to assess the efficacy of drugs in a short period of time. In this context, the reactivity of sera from 66 adults with chronic indeterminate Chagas disease (IND) for a set of fourTrypanosoma cruzi antigens (KMP11, PFR2, HSP70, and 3973d ) was analyzed before and after benznidazole treatment.

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